Product Information

Registration Status: Active

NARAMIG TABLET 2.5mg is approved to be sold in Singapore with effective from 1998-07-28. It is marketed by GLAXOSMITHKLINE PTE LTD, with the registration number of SIN09914P.

This product contains Naratriptan 2.5mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by GlaxoSmithKline Pharmaceuticals S.A. in POLAND.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.



Naratriptan is a triptan drug used for the treatment of migraine headaches. It is a selective 5-hydroxytryptamine1 receptor subtype agonist.


For the acute treatment of migraine attacks with or without aura in adults.

Mechanism of Action

Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves to inhibit both dural vasodilation and inflammation; (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism.


Well absorbed (74% oral biovaility), absorption is rapid with peak plasma concentrations after 2-5 hours. The rate of absorption is slower during a migraine attack.
* 170 L
Primarily hepatic. In vitro, naratriptan is metabolized by a wide range of cytochrome P450 isoenzymes into a number of inactive metabolites.


* 6.6 mL/min/kg


Symptoms of overdose include light-headedness, loss of coordination, tension in the neck, and tiredness.

Active Ingredient/Synonyms

N-Methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide | N-Methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide | Naratriptanum | Naratriptan |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank