Product Information
Registration Status: ActiveNATRILIX SR TABLET 1.5mg is approved to be sold in Singapore with effective from 1996-12-14. It is marketed by SERVIER (S) PTE LTD, with the registration number of SIN09074P.
This product contains Indapamide 1.5mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by LES LABORATOIRES SERVIER INDUSTRIE in FRANCE.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable. [PubChem]
Indication
For the treatment of hypertension, alone or in combination with other antihypertensive drugs, as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy (appropriate only in the management of edema of pathologic origin during pregnancy when clearly needed). Also used for the management of edema as a result of various causes.
Mechanism of Action
Indapamide blocks the slow component of delayed rectifier potassium current (IKs) without altering the rapid component (IKr) or the inward rectifier current. Specifically it blocks or antagonizes the action the proteins KCNQ1 and KCNE1. Indapamide is also thought to stimulate the synthesis of the vasodilatory hypotensive prostaglandin PGE2.
Pharmacokinetics
- Absorption
- Rapidly absorbed from gastrointestinal tract.
- Distribution
- Metabolism
- Primarily hepatic. Indapamide is an extensively metabolized drug with only about 7+ACU- of the total dose administered, recovered in the urine as unchanged drug during the first 48 hours after administration.
- Elimination
Toxicity
Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness
Active Ingredient/Synonyms
Indapamid | Indapamida | Indapamide | Indapamidum | Metindamide | Indapamide |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.