Product Information
Registration Status: ActiveNAUSICALM TABLET 50MG is approved to be sold in Singapore with effective from 2017-03-20. It is marketed by APEX PHARMA MARKETING PTE LTD, with the registration number of SIN15193P.
This product contains Cyclizine 50mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by Sigma Laboratories Ltd. in INDIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems).
Mechanism of Action
Vomiting (emesis) is essentially a protective mechanism for removing irritant or otherwise harmful substances from the upper GI tract. Emesis or vomiting is controlled by the vomiting centre in the medulla region of the brain, an important part of which is the chemotrigger zone (CTZ). The vomiting centre possesses neurons which are rich in muscarinic cholinergic and histamine containing synapses. These types of neurons are especially involved in transmission from the vestibular apparatus to the vomiting centre. Motion sickness principally involves overstimulation of these pathways due to various sensory stimuli. Hence the action of cyclizine which acts to block the histamine receptors in the vomiting centre and thus reduce activity along these pathways. Furthermore since cyclizine possesses anti-cholinergic properties as well, the muscarinic receptors are similarly blocked.
Active Ingredient/Synonyms
(+-)-1-Diphenylmethyl-4-methylpiperazine | (±)-1-diphenylmethyl-4-methylpiperazine | (N-Benzhydryl)(n'-methyl)diethylenediamine | 1-(Diphenylmethyl)-4-methylpiperazine | 1-Benzhydryl-4-methylpiperazin | Ciclizina | Cyclizine | Cyclizinum | N-Benzhydryl-N'-methylpiperazine | N-methyl-N'-benzhydrylpiperazine | Cyclizine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.