Product Information

Registration Status: Active

NESP INJECTION PLASTIC SYRINGE 40 MCG/0.5ML is approved to be sold in Singapore with effective from 2015-02-03. It is marketed by KYOWA KIRIN ASIA PACIFIC PTE LTD, with the registration number of SIN14742P.

This product contains Darbepoetin Alfa 40mcg in the form of INJECTION, SOLUTION, CONCENTRATE. It is approved for INTRAVENOUS, SUBCUTANEOUS use.

This product is manufactured by Terumo Corporation (Kofu Factory) in JAPAN.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Darbepoetin Alfa


Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.


For the treatment of anemia (from renal transplants or certain HIV treatment)

Mechanism of Action

Darbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Erythropoietin interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.

Active Ingredient/Synonyms

Darbepoetin | Darbepoetin alfa,recombinant | Darbepoetin alfa |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank