Product Information
Registration Status: ActiveNEVANAC EYE DROPS SUSPENSION 1mg/ML is approved to be sold in Singapore with effective from 2010-01-28. It is marketed by NOVARTIS (SINGAPORE) PTE LTD, with the registration number of SIN13759P.
This product contains Nepafenac 1mg/ml in the form of SUSPENSION, STERILE. It is approved for OPHTHALMIC use.
This product is manufactured by S.A. Alcon-Couvreur N.V. in BELGIUM.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Indication
For the treatment of pain and inflammation associated with cataract surgery.
Mechanism of Action
Nepafenac is a prodrug. After penetrating the cornea, nepafenac undergoes rapid bioactivation to amfenac, which is a potent NSAID that uniformly inhibits the COX1 and COX2 activity.
Pharmacokinetics
- Absorption
- Nepafenac rapidly cross the cornea (6 times faster than diclofenac in vitro).
- Distribution
- Metabolism
- Nepafenac (prodrug) is deaminated to amfenac (active compound) in the ciliary body epithelium, retina, and choroid by intraocular hydrolases. Subsequently, amfenac undergoes extensive metabolism to more polar metabolites involving hydroxylation of the aromatic ring leading to glucuronide conjugate formation.
- Elimination
Toxicity
Ocularly applied non-steroidal anti-inflammatory drugs may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery.
Active Ingredient/Synonyms
2-amino-3-Benzoylbenzeneacetamide | AHR 9434 | AL 6515 | Amfenac amide | Nepafenaco | Nepafenacum | Nepafenac |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.