Product Information

Registration Status: Active

NORADRENALINE AGUETTANT 1MG/ML CONCENTRATE FOR SOLUTION FOR INFUSION is approved to be sold in Singapore with effective from 2018-12-04. It is marketed by INTEGA PTE LTD, with the registration number of SIN15593P.

This product contains Noradrenaline 1mg/ml in the form of INFUSION, SOLUTION CONCENTRATE. It is approved for INTRAVENOUS use.

This product is manufactured by Laboratoire AGUETTANT - Lyon in FRANCE.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.



Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. [PubChem]


Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Mechanism of Action

Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it's activity at the beta-adrenergic receptors.


In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.

Active Ingredient/Synonyms

(-)-Arterenol | (-)-Noradrenaline | (-)-Norepinephrine | (R)-(-)-Norepinephrine | (R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol | (R)-Norepinephrine | 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol | Arterenol | L-noradrenaline | L-Norepinephrine | Nor-adrenaline | Noradrenaline | Norepinefrina | Norepinephrine | Norepinephrinum | Norepinephrine |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank