X

NOVOSEVEN POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 1MG

Product Information

Registration Status: Active

SIN13933P

NOVOSEVEN POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 1MG is approved to be sold in Singapore with effective from 2011-03-17. It is marketed by NOVO NORDISK PHARMA (SINGAPORE) PTE LTD, with the registration number of SIN13933P.

This product contains Eptacog Alfa 1mg in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.

This product is manufactured by Novo Nordisk A/S (DP and solvent in vials) in DENMARK, andNovo Nordisk A/S in GERMANY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
Loading...


Description

Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.

Indication

For treatment of hemorrhagic complications in hemophilia A and B

Mechanism of Action

NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin.

Clearance

* 33 - 37 mL/h x kg [healthy] * 1375 +/- 396 mL/hr [severe hemophilia A male children] * 57.3 +/- 9.5 mL/hr/kg [severe hemophilia A male children] * 2767 +/- 385 mL/hr [severe hemophilia A men] * 37.6 +/- 13.1 mL/hr/kg [severe hemophilia A men]

Active Ingredient/Synonyms

Coagulation factor VIIa | Coagulation factor VIIa (recombinant) | Eptacog alfa | Eptacog alfa (activated) | rFVIIa | Coagulation factor VIIa Recombinant Human |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

Pharmfair.com uses cookies to improve your browsing experience. We'll assume you're ok with this, but you can opt-out if you wish. Peace!