Product Information
Registration Status: ActiveOBAGI NU-DERM CLEAR is approved to be sold in Singapore with effective from 2008-08-13. It is marketed by ZOE NISSI PTE LTD, with the registration number of SIN13518P.
This product contains Hydroquinone 4% in the form of CREAM. It is approved for TOPICAL use.
This product is manufactured by Pure Tek Corporation in UNITED STATES.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. The topical application of monobenzone in animals increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation.
Indication
Used topically to treat the loss of skin color (vitiligo).
Mechanism of Action
Monobenzone is a depigmenting agent whose mechanism of action is not fully understood. The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation. This effect is erratic and may take one to four months to occur while existing melanin is lost with normal sloughing of the stratum corneum. Hyperpigmented skin appears to fade more rapidly than does normal skin, and exposure to sunlight reduces the depigmenting effect of the drug. The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes.
Active Ingredient/Synonyms
4-(Benzyloxy)phenol | 4-(Benzyloxyl)phenol | 4-(Phenylmethoxy)phenol | 4-Benzyloxy-phenol | 4-Benzyloxyphenol | Benzyl p-hydroxyphenyl ether | Hydrochinon monobenzylether | Hydroquinone benzyl ether | Hydroquinone monobenzyl ether | Monobenzona | Monobenzone | Monobenzonum | MONOBENZYL ether OF hydroquinone | Monobenzyl hydroquinone | p-(Benzyloxy)phenol | p-Hydroxyphenyl benzyl ether | Monobenzone |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.