Product InformationRegistration Status: Active
OLANZAPINE MEVON FILM-COATED TABLET 10mg is approved to be sold in Singapore with effective from 2012-09-13. It is marketed by NOVEM PHARMA PTE LTD, with the registration number of SIN14228P.
This product contains Olanzapine 10mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by Pharmathen S.A. in GREECE.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Olanzapine is an atypical antipsychotic, approved by the FDA in 1996. Olanzapine is manufactured and marketed by the pharmaceutical company Eli Lilly and Company, whose patent for olanzapine proper ends in 2011.
For the acute and maintenance treatment of schizophrenia and related psychotic disorders, as well as acute treatment of manic or mixed episodes of bipolar 1 disorder. Intramuscular olanzapine is indicated for the rapid control of agitated patients.
Mechanism of Action
Olanzapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia.
- Well absorbed, with approximately 40% of the dose metabolized before reaching the systemic circulation.
- * 1000 L
* 12 to 47 L/h
Symptoms of an overdose include tachycardia, agitation, dysarthria, decreased consciousness and coma. Death has been reported after an acute overdose of 0.45g, but also survival after an acute overdose of 1500g.
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine | Olanzapin | Olanzapina | Olanzapine | Olanzapinum | Olanzapine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.