Product Information
Registration Status: ActiveONADRINE TABLET 50mg is approved to be sold in Singapore with effective from 1994-01-18. It is marketed by SUNWARD PHARMACEUTICAL PTE LTD, with the registration number of SIN07611P.
This product contains Orphenadrine 50mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by SUNWARD PHARMACEUTICAL PRIVATE LIMITED in SINGAPORE, andSUNWARD PHARMACEUTICAL SDN BHD in MALAYSIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. [PubChem]
Indication
Indicated for the treatment of Parkinson's disease.
Mechanism of Action
Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect.
Pharmacokinetics
- Absorption
- Orphenadrine is almost completely absorbed in the gastrointestinal tract.
- Distribution
- Metabolism
- Biotransformation occurs mainly in the liver. Pharmacologically active metabolites are N-demethyl orphenadrine and N,N-didemethyl orphenadrine.
- Elimination
Toxicity
Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg
Active Ingredient/Synonyms
2-(phenyl-o-tolylmethoxy)ethyldimethylamine | 2-methyldiphenhydramine | beta-Dimethylaminoethyl 2-methylbenzhydryl ether | Dimethyl-[2-(phenyl-O-tolyl-methoxy)-ethyl]-amine | N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine | N,N-Dimethyl-2-(phenyl(O-tolyl)methoxy)ethanamine | N,N-Dimethyl-2-[(O-methyl-alpha-phenylbenzyl)oxy]ethylamine | o-methyldiphenhydramine | o-monomethyldiphenhydramine | Orfenadrina | ORPHENADRINE | Orphenadrinum | Phenyl-O-tolylmethyl dimethyaminoethyl ether | β-dimethylaminoethyl 2-methylbenzhydryl ether | Orphenadrine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.