Product Information
Registration Status: ActivePANBESY CAPSULE 15mg is approved to be sold in Singapore with effective from 1991-07-01. It is marketed by EURO ASIA MEDICO PTE LTD, with the registration number of SIN05315P.
This product contains Phentermine 15mg in the form of CAPSULE. It is approved for ORAL use.
This product is manufactured by OSMOPHARM SA in SWITZERLAND, andTjoapack Netherlands B.V (Primary Packager) in NETHERLANDS.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]. Some common brand names for phentermine are Adipex-P® and Suprenza™. Phentermine is also available in combination medications such as Qsymia®.
Indication
For the treatment and management of obesity.
Mechanism of Action
Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse.Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
Pharmacokinetics
- Absorption
- Phentermine is rapidly absorbed after oral ingestion.
- Distribution
- Metabolism
- Hepatic.
- Elimination
Toxicity
LD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
Active Ingredient/Synonyms
alpha,alpha-Dimethylphenethylamine | Fentermina | Phentermine resin | Phenterminum | Phentermine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.