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PAZEO OPHTHALMIC SOLUTION 0.7%

Product Information

Registration Status: Active

SIN15242P

PAZEO OPHTHALMIC SOLUTION 0.7% is approved to be sold in Singapore with effective from 2017-05-22. It is marketed by NOVARTIS (SINGAPORE) PTE LTD, with the registration number of SIN15242P.

This product contains Olopatadine 0.70% in the form of SOLUTION, STERILE. It is approved for OPHTHALMIC use.

This product is manufactured by Alcon Laboratories in UNITED STATES, and Inc. in BELGIUM.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

Used to treat allergic conjunctivitis (itching eyes), olopatadine inhibits the release of histamine from mast cells. It is a relatively selective histamine H1 antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells.

Indication

For the treatment of ocular itching associated with allergic conjunctivitis.

Mechanism of Action

Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Olopatadine is devoid of effects on alpha-adrenergic, dopamine and muscarinic type 1 and 2 receptors.

Pharmacokinetics

Absorption
Ophthalmic use of olopatadine usually does not produce measurable plasma concentrations.
Distribution
Metabolism
The mono-desmethyl and the N-oxide metabolites have been detected at low concentrations in the urine.
Elimination

Active Ingredient/Synonyms

Olopatadin | Olopatadina | Olopatadine | Olopatadinum | Opatanol | Olopatadine |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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