Product Information
Registration Status: ActiveSIN14854P
PENTHROX INHALATION LIQUID 99.9% is approved to be sold in Singapore with effective from 2015-09-21. It is marketed by LINK HEALTHCARE SINGAPORE PTE LTD, with the registration number of SIN14854P.
This product contains Methoxyflurane 99.9 percent in the form of INHALANT. It is approved for RESPIRATORY (INHALATION) use.
This product is manufactured by Medical Developments International LTD (MDI) in AUSTRALIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
Indication
For use in the induction and maintenance of general anesthesia
Mechanism of Action
Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Toxicity
LD50=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.
Active Ingredient/Synonyms
Methoflurane | Methoxyfluoran | Methoxyfluran | Methoxyfluranum | Methyl 1,1-difluoro-2,2-dichloroethyl ether | Metoxiflurano | Methoxyflurane |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.