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PIPERACILLIN-TAZOBACTAM STRAGEN FOR INJECTION 4.5G/VIAL

Product Information

Registration Status: Active

SIN13978P

PIPERACILLIN-TAZOBACTAM STRAGEN FOR INJECTION 4.5G/VIAL is approved to be sold in Singapore with effective from 2011-06-20. It is marketed by NOVEM HEALTHCARE PTE LTD, with the registration number of SIN13978P.

This product contains Piperacillin 4000mg, and Tazobactam 500mg in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.

This product is manufactured by MITIM S.r.l. in ITALY, andFresenius Kabi Ipsum S.R.L. (sterile bulk) Muggio site in CHINA.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. [PubChem]

Indication

For the treatment of polymicrobial infections.

Mechanism of Action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.

Pharmacokinetics

Absorption
Not absorbed following oral administration.
Distribution
* 101 mL/kg [intravenous administration of 50 mg/kg (5-minute infusion) in neonates]
Metabolism
Largely not metabolized.
Elimination

Clearance

* 32 - 41 mL/min/1.73 m2 * 124 - 160 mL/min/1.73 m2 [older pediatric patients]

Active Ingredient/Synonyms

(2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | Piperacilina | Piperacillin | Piperacillin Anhydrous | Piperacillina | Pipéracilline | Piperacillinum | Piperacillin |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


Description

Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

Indication

Used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action.

Mechanism of Action

Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.

Active Ingredient/Synonyms

CL-298741 | Tazobactam | YTR-830H | Tazobactam |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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