Product Information
Registration Status: ActiveSIN08049P
PMS-CHLORAL HYDRATE SYRUP 500mg/5ml is approved to be sold in Singapore with effective from 1995-02-23. It is marketed by MEDICELL PHARMACEUTICAL (S) PTE LTD, with the registration number of SIN08049P.
This product contains Chloral Hydrate 500mg/5ml in the form of SYRUP. It is approved for ORAL use.
This product is manufactured by Pendopharm in CANADA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.
Indication
Mainly used as a hyponotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
Pharmacokinetics
- Absorption
- Rapidly absorbed in the GI tract following oral or rectal administration. Chloral hydrate and its active metabolite, trichloroethanol, have been detected in CSF, umbilical cord blood, fetal blood, and amniotic fluid.
- Distribution
- Metabolism
- Metabolized by the liver and erythrocytes to form trichloroethanol, an active metabolite. This reaction is catalyzed by alcohol dehydrogenase and other enzymes. Oxidation of chloral hydrate and trichloroethanol to trichloroacetic acid in the liver and kidneys also occurs to a lesser extent. Trichloroethanol also undergoes glucuronidation to produce an inactive metabolism.
- Elimination
Active Ingredient/Synonyms
1,1,1-trichloro-2,2-dihydroxyethane | 1,1,1-trichloro-2,2-ethanediol | 2,2,2-trichloro-1,1-ethanediol | chloral monohydrate | Chloralhydrat | Trichloracetaldehyd-hydrat | trichloroacetaldehyde hydrate | Chloral hydrate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.