Product InformationRegistration Status: Active
PONTACID CAPSULE 250mg is approved to be sold in Singapore with effective from 1990-05-03. It is marketed by DUOPHARMA (SINGAPORE) PTE LTD, with the registration number of SIN03923P.
This product contains Mefenamic Acid 250mg in the form of CAPSULE. It is approved for ORAL use.
This product is manufactured by DUOPHARMA (M) SDN BHD in MALAYSIA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. [PubChem]
For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.
Mechanism of Action
Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
- Mefenamic acid is rapidly absorbed after oral administration.
- * 1.06 L/kg [Normal Healthy Adults (18-45 yr)]
- Mefenamic acid undergoes metabolism by CYP2C9 to 3-hydroxymethyl mefenamic acid, and further oxidation to a 3-carboxymefenamic acid may occur. The activity of these metabolites has not been studied. Mefenamic acid is also glucuronidated directly.
* Oral cl=21.23 L/hr [Healthy adults (18-45 yrs)]
Oral, rat LD50: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.
Acide méfénamique | Acido mefenamico | Acidum mefenamicum | CN 35355 | INF 3355 | Mefenaminsaeure | Mefenaminsäure | N-(2,3-Xylyl)-2-aminobenzoic acid | N-2,3-Xylylanthranilic acid | Mefenamic acid |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.