PRIFTIN FILM COATED TABLETS 150MG FOR ORAL USE

Product Information

Registration Status: Active

PRIFTIN FILM COATED TABLETS 150MG is approved to be sold in Singapore with effective from 2019-09-02. It is marketed by SANOFI-AVENTIS SINGAPORE PTE LTD, with the registration number of SIN15793P.

This product contains Rifapentine 150mg in the form of TABLET, FILM COATED. It is approved for ORAL use.

This product is manufactured by Sanofi S.p.A in ITALY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Description

Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Indication

For the treatment of pulmonary tuberculosis.

Mechanism of Action

Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentine acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

Pharmacokinetics

Absorption: Rapidly and well absorbed from the gastrointestinal tract.
Distribution: * 70.2 ± 9.1 L
Metabolism: Hepatic
Elimination

Clearance

* Apparent Oral cl=2.51 +/- 0.14 L/h [Male tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol] * Apparent Oral cl=1.69 +/- 0.41 L/h [Female tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]

Active Ingredient/Synonyms

3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin | Cyclopentylrifampicin | Priftin (tn) | Rifapentine |

Source of information: Drugbank (External Link). Last updated on: 3^rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.