Product InformationRegistration Status: Active
PROCARDIN 75 TABLET 75mg is approved to be sold in Singapore with effective from 1988-06-04. It is marketed by MEDOCHEMIE SINGAPORE PTE LTD, with the registration number of SIN00263P.
This product contains Dipyridamole 75mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by MEDOCHEMIE LTD in CYPRUS.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.
Mechanism of Action
Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.
- * 1 to 2.5 L/kg
* 2.3-3.5 mL/min/kg
Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD50 in rats is greater than 6,000 mg/kg while in the dogs, the oral LD50 is approximately 400 mg/kg. LD50=8.4g/kg (orally in rat)
Cleridium 150 | Curantyl | Dipiridamol | Dipyridamine | Dipyridamolum | Dipyudamine | Dypyridamol | Persantin | Dipyridamole |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.