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PROCUR TABLET 50MG

Product Information

Registration Status: Active

SIN13545P

PROCUR TABLET 50MG is approved to be sold in Singapore with effective from 2008-08-29. It is marketed by GOOD PHARMACEUTICAL PTE LTD, with the registration number of SIN13545P.

This product contains Cyproterone 50mg in the form of TABLET. It is approved for ORAL use.

This product is manufactured by DOUGLAS MANUFACTURING LTD in NEW ZEALAND.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]

Indication

For the palliative treatment of patients with advanced prostatic carcinoma.

Mechanism of Action

The direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone.

Pharmacokinetics

Absorption
Completely absorbed following oral administration.
Distribution
Metabolism
Primarily hepatic. Cyproterone acetate is metabolized by the CYP3A4 enzyme, forming the active metabolite 15beta-hydroxycyproterone acetate, which retains its antiandrogen activity, but has reduced progestational activity.
Elimination

Active Ingredient/Synonyms

Cyproterone 17-O-acetate | Cyproterone acetate |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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