Product Information
Registration Status: ActiveSIN10798P
PROLEUKIN POWDER FOR INFUSION 18 MIU/VIAL is approved to be sold in Singapore with effective from 1999-12-03. It is marketed by LINK HEALTHCARE SINGAPORE PTE LTD, with the registration number of SIN10798P.
This product contains Aldesleukin 18 miu/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.
This product is manufactured by BAYER HEALTHCARE PHARMACEUTICALS INC. in UNITED STATES, andBoehringer Ingelheim Pharma GmbH & Co KG in GERMANY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
Indication
For treatment of adults with metastatic renal cell carcinoma.
Mechanism of Action
Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.
Active Ingredient/Synonyms
125-L-serine-2-133-interleukin 2 (human reduced) | Interleukin-2 aldesleukin | Interleukin-2(2-133),125-ser | Recombinant interleukin-2 human | Aldesleukin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.