PROPANOL TABLET 40mg

Product Information

Registration Status: Active

PROPANOL TABLET 40mg is approved to be sold in Singapore with effective from 1988-02-06. It is marketed by BEACONS PHARMACEUTICALS PTE LTD, with the registration number of SIN01621P.

This product contains Propranolol 40mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by BEACONS PHARMACEUTICALS PTE LTD in SINGAPORE.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Propranolol

Description

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]

Indication

For the prophylaxis of migraine.

Mechanism of Action

Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.

Pharmacokinetics

Absorption
Propranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals.
Distribution
* 4 L
Metabolism
Hepatic
Elimination

Toxicity

Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. LD50=565 mg/kg (orally in mice).

Active Ingredient/Synonyms

1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol | 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol | beta-Propranolol | Propanalol | Propanolol | Propranolol | Propranololo | Propranololum | β-Propranolol | Propranolol |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank