Product Information
Registration Status: ActivePROPYLTHIOURACIL TABLET BP 50mg is approved to be sold in Singapore with effective from 1988-04-05. It is marketed by DRUG HOUSES OF AUSTRALIA PTE LTD, with the registration number of SIN00772P.
This product contains Propylthiouracil 50mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by PT ACTAVIS INDONESIA in INDONESIA REP OF.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Indication
Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).
Mechanism of Action
Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.
Pharmacokinetics
- Absorption
- Well absorbed following oral administration.
- Distribution
- Metabolism
- Elimination
Toxicity
Oral, rat: LD50 = 1250 mg/kg.
Active Ingredient/Synonyms
2-Mercapto-6-propyl-4-pyrimidone | 2-Mercapto-6-propylpyrimid-4-one | 2-Thio-4-oxo-6-propyl-1,3-pyrimidine | 2-Thio-6-propyl-1,3-pyrimidin-4-one | 2,3-dihydro-6-Propyl-2-thioxo-4(1H)-pyrimidinone | 4-Propyl-2-thiouracil | 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione | 6-Propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one | 6-Propylthiouracil | 6-Thio-4-propyluracil | Propiltiouracilo | Propylthiouracil | Propylthiouracile | Propylthiouracilum | Propylthiouracil |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.