RELESTAT OPHTHALMIC SOLUTION 0.5mg/ML

Product Information

Registration Status: Active

RELESTAT OPHTHALMIC SOLUTION 0.5mg/ML is approved to be sold in Singapore with effective from 2010-06-15. It is marketed by ALLERGAN SINGAPORE PTE LTD, with the registration number of SIN13817P.

This product contains Epinastine 0.05% w/v in the form of SOLUTION, STERILE. It is approved for OPHTHALMIC use.

This product is manufactured by Allergan Pharmaceuticals Ireland in IRELAND.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Epinastine

Description

Epinastine is used for the prevention of itching associated with allergic conjunctivitis. It has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and H2-receptors to stop itching and provide lasting protection, and 3. prevents the release of proinflammatory chemical mediators from the blood vessel to halt progression of the allergic response.

Indication

For the prevention of itching associated with allergic conjunctivitis.

Mechanism of Action

Epinastine has a multiaction effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and H2-receptors to stop itching and provide lasting protection, and 3. prevents the release of proinflammatory chemical mediators from the blood vessel to halt progression of the allergic response.

Pharmacokinetics

Absorption
The absolute bioavailability of epinastine is about 40%.
Distribution
Metabolism
Mainly excreted unchanged, less than 10% metabolized.
Elimination

Clearance

* 56 L/hr [patients with allergic conjunctivitis receiving one drop of ELESTAT® ophthalmic solution in each eye twice daily for seven days]

Active Ingredient/Synonyms

(+-)-Epinastine | 3-amino-9,13b-dihydro-1H-Dibenz(c,F)imidazo(1,5-a)azepine | Epinastin | Epinastina | Epinastine | Epinastinum | Epinastine |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank