Product Information

Registration Status: Active

REMINYL PROLONGED RELEASE CAPSULE 24mg is approved to be sold in Singapore with effective from 2004-10-08. It is marketed by JOHNSON & JOHNSON PTE LTD, with the registration number of SIN13021P.

This product contains Galantamine 24mg in the form of CAPSULE,-COATED, EXTENDED-RELEASE. It is approved for ORAL use.

This product is manufactured by JANSSEN PHARMACEUTICA NV in BELGIUM, andJANSSEN-CILAG SPA (Encapsulation) in ITALY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.



A benzazepine derived from norbelladine. It is found in galanthus and other amaryllidaceae. Galantamine is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine, and has been studied as a treatment for Alzheimer's disease and other central nervous system disorders.


For the treatment of mild to moderate dementia of the Alzheimer's type. Has also been investigated in patients with mild cognitive impairment who did not meet the diagnostic criteria for Alzheimer's disease.

Mechanism of Action

Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor. It is not structurally related to other acetylcholinesterase inhibitors. Galantamine's proposed mechanism of action involves the reversible inhibition of acetylcholinesterase, which prevents the hydrolysis of acetycholine, leading to an increased concentration of acetylcholine at cholinergic synapses. Galantamine also binds allosterically with nicotinic acetylcholine receptors and may possibly potentiate the action of agonists (such as acetylcholine) at these receptors.


* 300 mL/min [After IV. or oral administration]


LD50=75 mg/kg (rat)

Active Ingredient/Synonyms

(-)-Galanthamine | Galanthamine | Galantamine |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank