X

RESOLOR FILM-COATED TABLET 1mg

Product Information

Registration Status: Active

SIN14103P

RESOLOR FILM-COATED TABLET 1mg is approved to be sold in Singapore with effective from 2012-02-14. It is marketed by JOHNSON & JOHNSON PTE LTD, with the registration number of SIN14103P.

This product contains Prucalopride 1mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by Janssen Cilag S.p.A. in ITALY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
Loading...


Description

Prucalopride (brand name Resolor, developed by Johnson & Johnson and licensed to Movetis) is a drug acting as a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements. Prucalopride was approved for use in Europe in 2009 and in Canada (named Resotran) on December 7, 2011 but it has not been approved by the Food and Drug Administration for use in the United States. The drug has also been tested for the treatment of chronic intestinal pseudo-obstruction.

Indication

Investigated for use/treatment in constipation, ileus, and pediatric indications.

Mechanism of Action

Prucalopride (PRU) is a selective high affinity 5-HT4 agonist, which are involved in initiating peristalsis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.

Pharmacokinetics

Absorption
Prucalopride is rapidly absorbed (Cmax attained 2–3 hours after single 2 mg oral dose) and is extensively distributed.
Distribution
Metabolism
In vitro, human liver metabolism is very slow and only minor amounts of metabolites are found.
Elimination

Active Ingredient/Synonyms

Prucalopride | Prucalopride |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

Pharmfair.com uses cookies to improve your browsing experience. We'll assume you're ok with this, but you can opt-out if you wish. Peace!