X

RIFAMPICIN CAPSULE 150mg

Product Information

Registration Status: Active

SIN02050P

RIFAMPICIN CAPSULE 150mg is approved to be sold in Singapore with effective from 1988-06-23. It is marketed by BEACONS PHARMACEUTICALS PTE LTD, with the registration number of SIN02050P.

This product contains Rifampicin 150mg in the form of CAPSULE. It is approved for ORAL use.

This product is manufactured by BEACONS PHARMACEUTICALS PTE LTD in SINGAPORE.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
Loading...


Description

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

Indication

For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.

Mechanism of Action

Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

Pharmacokinetics

Absorption
Well absorbed from gastrointestinal tract.
Distribution
Metabolism
Primarily hepatic, rapidly deacetylated.
Elimination

Clearance

* 0.19 +/- 0.06 L/hr/kg [300 mg IV] * 0.14 +/- 0.03 L/hr/kg [600 mg IV]

Toxicity

LD50=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness

Active Ingredient/Synonyms

3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV | RFP | Rifampicina | Rifampicinum | Rifampin | Rifampicin |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

Pharmfair.com uses cookies to improve your browsing experience. We'll assume you're ok with this, but you can opt-out if you wish. Peace!