X

RISEDRONATE MEVON FILM-COATED TABLET 35MG

Product Information

Registration Status: Active

SIN13798P

RISEDRONATE MEVON FILM-COATED TABLET 35MG is approved to be sold in Singapore with effective from 2010-05-14. It is marketed by NOVEM PHARMA PTE LTD, with the registration number of SIN13798P.

This product contains Risedronic Acid 32.5mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by Pharmathen S.A. in GREECE.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
Loading...


Description

Risedronate is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.

Indication

For the treatment of Paget's disease of the bone (osteitis deformans), postmenopausal and glucocorticoid-induced osteoporosis

Mechanism of Action

The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Pharmacokinetics

Absorption
Rapid absorption (~1 hr) after an oral dose, occurs throughout the upper gastrointestinal tract
Distribution
* 13.8 L/kg
Metabolism
No evidence found for metabolization of risedronate in humans or mammals
Elimination

Clearance

* 122 mL/min * 73 mL/min [osteopenic postmenopausal women]

Toxicity

Side effects include abdominal pain, anxiety, back pain, belching, bladder irritation, bone disorders and pain, bronchitis, bursitis, cataracts, chest pain, colitis, constipation, depression, diarrhea, difficulty breathing, dizziness, dry eyes, eye infection, flu-like symptoms, gas, headache, high blood pressure, infection, insomnia, itching, joint disorders and pain, leg cramps, muscle pain, muscle weakness, nausea, neck pain, nerve pain, pain, pneumonia, rash, ringing in ears, sinus problems, sore throat, stomach bleeding, stuffy or runny nose, swelling, tendon problems, tumor, ulcers, urinary tract infection, vertigo, vision problems, and weakness.

Active Ingredient/Synonyms

Acide risédroniqe | Acido risedronico | Acidum risedronicum | Ridron | Risedronate | Risedronic acid | Risedronsäure | Risedronate |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

Pharmfair.com uses cookies to improve your browsing experience. We'll assume you're ok with this, but you can opt-out if you wish. Peace!