Product Information
Registration Status: ActiveSIN06131P
ROSIDEN CAPSULE 20mg is approved to be sold in Singapore with effective from 1991-05-22. It is marketed by ZYFAS MEDICAL CO, with the registration number of SIN06131P.
This product contains Piroxicam 20mg in the form of CAPSULE. It is approved for ORAL use.
This product is manufactured by SHIN POONG PHARMACEUTICAL CO LTD in KOREA, and in REPUBLIC OF.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. [PubChem]
Indication
For treatment of osteoarthritis and rheumatoid arthritis.
Mechanism of Action
The antiinflammatory effect of Piroxicam may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by an enzyme called Cox-1. Piroxicam blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. Piroxicam also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.
Pharmacokinetics
- Absorption
- Well absorbed following oral administration.
- Distribution
- * 0.14 L/kg
- Metabolism
- Renal
- Elimination
Toxicity
Symptoms of overdose include drowsiness, nausea, stomach pain, and/or vomiting.
Active Ingredient/Synonyms
4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid | Piroxicam | Piroxicam betadex | Piroxicamum | Pyroxycam | Piroxicam |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.