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SALAGEN TABLET 5mg

Product Information

Registration Status: Active

SIN11683P

SALAGEN TABLET 5mg is approved to be sold in Singapore with effective from 2001-09-28. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN11683P.

This product contains Pilocarpine 5mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by PATHEON YM INC in CANADA.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. [PubChem]

Indication

For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.

Mechanism of Action

Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.

Pharmacokinetics

Absorption
There was a decrease in the rate of absorption of pilocarpine from SALAGEN Tablets when taken with a high fat meal by 12 healthy male volunteers
Distribution
Metabolism
Possibly occurs at the neuronal synapses and in the plasma
Elimination

Active Ingredient/Synonyms

(3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone | (3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone | Pilocarpine | Pilocarpine |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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