Product Information
Registration Status: ActiveSIN10131P
SILVIN CREAM is approved to be sold in Singapore with effective from 1998-02-10. It is marketed by ICM PHARMA PTE LTD, with the registration number of SIN10131P.
This product contains Chlorhexidine Digluconate 0.2% w/v, and Silver Sulphadiazine 1% w/v in the form of CREAM. It is approved for TOPICAL use.
This product is manufactured by ICM PHARMA PTE LTD in SINGAPORE.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.
Indication
Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Mechanism of Action
Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine's effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Pharmacokinetics
- Absorption
- Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
- Distribution
- Metabolism
- Elimination
Toxicity
Acute oral toxicity (LD50) in rat is 10001 mg/kg.
Active Ingredient/Synonyms
Silver sulfadiazinate | Silver sulfadiazine | Silver sulphadiazine | Sulfadiazine silver | Sulfadiazine silver salt | Silver sulfadiazine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.