Product Information
Registration Status: ActiveSIN14780P
SOJOURN INHALATION ANAESTHETIC LIQUID 100% is approved to be sold in Singapore with effective from 2015-08-05. It is marketed by EMERGING PHARMA (S) PTE LTD, with the registration number of SIN14780P.
This product contains Sevoflurane 100% v/v in the form of INHALANT. It is approved for RESPIRATORY (INHALATION) use.
This product is manufactured by Piramal Critical Care Inc. in UNITED STATES.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology.
Indication
Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Mechanism of Action
Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase and also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor, and the glycine receptor.
Pharmacokinetics
- Absorption
- Rapidly absorbed into circulation via the lungs, however solubility in the blood is low.
- Distribution
- Metabolism
- Relatively little biotransformation, only 5% is metabolized by cytochrome P450 CYP2E1 to hexafluoroisopropanol (HFIP) with release of inorganic fluoride and CO2. No other metabolic pathways have been identified for sevoflurane.
- Elimination
Toxicity
LC50=49881 ppm/hr (rat), LD50=10.8 g/kg (rat)
Active Ingredient/Synonyms
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane | Sevofluran | Sevoflurane | Sevoflurano | Sevofluranum | Sevoflurane |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.