Product InformationRegistration Status: Active
SOLU-MEDROL FOR INJECTION 500mg/8ml is approved to be sold in Singapore with effective from 1990-06-13. It is marketed by PFIZER PTE LTD, with the registration number of SIN04683P.
This product contains Methylprednisolone 500mg/8ml in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS, INTRAMUSCULAR use.
This product is manufactured by PFIZER MANUFACTURING BELGIUM NV in BELGIUM.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
A prednisolone derivative with similar anti-inflammatory action. [PubChem]
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Mechanism of Action
Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
- Oral bioavailability 80-99%
LD50=2000 mg/kg (orally in rat)
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione | (6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione | 1-dehydro-6alpha-Methylhydrocortisone | 1-dehydro-6α-methylhydrocortisone | 6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione | delta(1)-6alpha-Methylhydrocortisone | Medrate | Medrone | Methylprednisolon | Methylprednisolone | Methylprednisolonum | Metilprednisolona | Solomet | Urbason | Methylprednisolone |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.