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SULPIDIN TABLET 200mg

Product Information

Registration Status: Active

SIN11957P

SULPIDIN TABLET 200mg is approved to be sold in Singapore with effective from 2002-05-25. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN11957P.

This product contains Sulpiride 200mg in the form of TABLET. It is approved for ORAL use.

This product is manufactured by MYUNG IN PHARM CO LTD in KOREA, and in REPUBLIC OF.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)

Indication

Sulpiride is indicated for the treatment of schizophrenia.

Mechanism of Action

In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.

Pharmacokinetics

Absorption
Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.
Distribution
Metabolism
Elimination

Toxicity

Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.

Active Ingredient/Synonyms

(+-)-Sulpiride | 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide | Levosulpirida | Levosulpiride | Levosulpiridum | N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide | N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-O-anisamide | Sulpirid | Sulpirida | Sulpiridum | Sulpyrid | Sulpiride |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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