Product Information
Registration Status: ActiveSIN08818P
SUPRANE INHALATION ANAESTHETIC is approved to be sold in Singapore with effective from 1996-06-08. It is marketed by BAXTER HEALTHCARE (ASIA) PTE LTD, with the registration number of SIN08818P.
This product contains Desflurane 100% in the form of SOLUTION. It is approved for NASAL use.
This product is manufactured by Baxter Healthcare Corporation in UNITED STATES.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors.
Indication
For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
Mechanism of Action
Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Desflurane also binds to and agonizes the GABA receptor, the large conductance Ca2+ activated potassium channel, the glycine receptors, and antagonizes the glutamate receptors.
Pharmacokinetics
- Absorption
- Rapidly absorbed into the circulation via the lungs following inhalation.
- Distribution
- Metabolism
- Minimally biotransformed in the liver in humans (approximately 0.02% of the quantity absorbed).
- Elimination
Active Ingredient/Synonyms
(+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether | 1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane | Desflurane | Desflurano | Desfluranum | Difluoromethyl 1,2,2,2-tetrafluoroethyl ether | Desflurane |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.