Product Information
Registration Status: ActiveTAFLOTAN OPHTHALMIC SOLUTION 0.0015% is approved to be sold in Singapore with effective from 2010-07-10. It is marketed by SANTEN PHARMACEUTICAL ASIA PTE LTD, with the registration number of SIN13872P.
This product contains Tafluprost 0.015mg/ml in the form of SOLUTION, STERILE. It is approved for OPHTHALMIC use.
This product is manufactured by Santen Pharmaceutical Co. in JAPAN.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.
Indication
Tafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Mechanism of Action
Tafluprost acid is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and humans suggest that the main mechanism of action is increased uveoscleral outflow.
Pharmacokinetics
- Absorption
- Following instillation, tafluprost is absorbed through the cornea and is hydrolyzed to the biologically active acid metabolite, tafluprost acid. Tafluprost is an ester which makes the drug lipophillic enough to be quickly absorbed through. When administered to the eye, the peak plasma concentration (Cmax) and time to peak plasma concentration (Tmax) of tafluprost acid in healthy subjects was 26 pg/mL and 10 minutes respectively. a AUC, tafluprost acid = 394 pg*min/mL - 432 pg*min/mL.
- Distribution
- The highest concentration of tafluprost acid was found in the cornea and conjunctiva.
- Metabolism
- Tafluprost is an ester prodrug which is rapidly hydrolyzed by corneal esterases to form its biologically active acid metabolite. Tafluprost acid is further metabolized via fatty acid β-oxidation and phase II conjugation into 1,2,3,4-tetranor acid.
- Elimination
Toxicity
Most common ocular adverse reaction is conjunctival hyperemia (range 4% – 20%).
Active Ingredient/Synonyms
AFP-168 | Tafluprost |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.