Product Information
Registration Status: ActiveTAZOCIN FOR INJECTION 4.5g/VIAL is approved to be sold in Singapore with effective from 1995-03-10. It is marketed by PFIZER PTE LTD, with the registration number of SIN08362P.
This product contains Piperacillin 4000mg/vial, and Tazobactam 500mg/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS, INTRAMUSCULAR use.
This product is manufactured by Wyeth Lederle S.r.l in TAIWAN, andPfizer Biotech Corporation in ITALY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. [PubChem]
Indication
For the treatment of polymicrobial infections.
Mechanism of Action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.
Pharmacokinetics
- Absorption
- Not absorbed following oral administration.
- Distribution
- * 101 mL/kg [intravenous administration of 50 mg/kg (5-minute infusion) in neonates]
- Metabolism
- Largely not metabolized.
- Elimination
Clearance
* 32 - 41 mL/min/1.73 m2 * 124 - 160 mL/min/1.73 m2 [older pediatric patients]
Active Ingredient/Synonyms
(2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | Piperacilina | Piperacillin | Piperacillin Anhydrous | Piperacillina | Pipéracilline | Piperacillinum | Piperacillin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.
Indication
Used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action.
Mechanism of Action
Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
Active Ingredient/Synonyms
CL-298741 | Tazobactam | YTR-830H | Tazobactam |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.