TAZOCIN FOR INJECTION 4.5g/VIAL

Product Information

Registration Status: Active

TAZOCIN FOR INJECTION 4.5g/VIAL is approved to be sold in Singapore with effective from 1995-03-10. It is marketed by PFIZER PTE LTD, with the registration number of SIN08362P.

This product contains Piperacillin 4000mg/vial, and Tazobactam 500mg/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS, INTRAMUSCULAR use.

This product is manufactured by Wyeth Lederle S.r.l in TAIWAN, andPfizer Biotech Corporation in ITALY.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Piperacillin
Tazobactam

Description

Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. [PubChem]

Indication

For the treatment of polymicrobial infections.

Mechanism of Action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.

Pharmacokinetics

Absorption
Not absorbed following oral administration.
Distribution
* 101 mL/kg [intravenous administration of 50 mg/kg (5-minute infusion) in neonates]
Metabolism
Largely not metabolized.
Elimination

Clearance

* 32 - 41 mL/min/1.73 m2 * 124 - 160 mL/min/1.73 m2 [older pediatric patients]

Active Ingredient/Synonyms

(2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | Piperacilina | Piperacillin | Piperacillin Anhydrous | Piperacillina | Pipéracilline | Piperacillinum | Piperacillin |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


Description

Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

Indication

Used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action.

Mechanism of Action

Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.

Active Ingredient/Synonyms

CL-298741 | Tazobactam | YTR-830H | Tazobactam |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank