Product Information
Registration Status: ActiveTOBRA EYE DROP is approved to be sold in Singapore with effective from 2004-12-16. It is marketed by ZIWELL MEDICAL (S) PTE LTD, with the registration number of SIN12627P.
This product contains Tobramycin 300mg in the form of SOLUTION. It is approved for OPHTHALMIC use.
This product is manufactured by DAEWOONG PHARMACEUTICAL CO LTD (SUNGNAM CITY) in KOREA, and in REPUBLIC OF.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by the same species. [PubChem]
Indication
For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.
Mechanism of Action
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.
Pharmacokinetics
- Absorption
- The bioavailability of tobramycin may vary because of individual differences in nebulizer performance and airway pathology.
- Distribution
- Metabolism
- Elimination
Toxicity
LD50=441mg/kg (s.c. in mice)
Active Ingredient/Synonyms
3'-Deoxykanamycin b | Nebramycin 6 | Nebramycin factir 6 | Nebramycin-Faktor 6 | O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine | Tobracin (tn) | Tobramicina | Tobramycin | Tobramycine | Tobramycinum | Tobrex (tn) | Tobramycin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.