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TOBREX STERILE OPHTHALMIC SOLUTION 0.3%

Product Information

Registration Status: Active

SIN04451P

TOBREX STERILE OPHTHALMIC SOLUTION 0.3% is approved to be sold in Singapore with effective from 1990-05-22. It is marketed by NOVARTIS (SINGAPORE) PTE LTD, with the registration number of SIN04451P.

This product contains Tobramycin 3mg/ml in the form of SOLUTION. It is approved for OPHTHALMIC use.

This product is manufactured by ALCON-COUVREUR NV in SINGAPORE, andALCON SINGAPORE MANUFACTURING PTE. LTD. in BELGIUM.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by the same species. [PubChem]

Indication

For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.

Mechanism of Action

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.

Pharmacokinetics

Absorption
The bioavailability of tobramycin may vary because of individual differences in nebulizer performance and airway pathology.
Distribution
Metabolism
Elimination

Toxicity

LD50=441mg/kg (s.c. in mice)

Active Ingredient/Synonyms

3'-Deoxykanamycin b | Nebramycin 6 | Nebramycin factir 6 | Nebramycin-Faktor 6 | O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine | Tobracin (tn) | Tobramicina | Tobramycin | Tobramycine | Tobramycinum | Tobrex (tn) | Tobramycin |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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