Product Information
Registration Status: ActiveSIN11216P
TROPIN 200 INJECTION 200mg/5ml is approved to be sold in Singapore with effective from 1999-04-11. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN11216P.
This product contains Dopamine 200mg/5ml in the form of INJECTION. It is approved for INTRAVENOUS use.
This product is manufactured by HANLIM PHARMACEUTICAL CO LTD in KOREA, and in REPUBLIC OF.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Indication
For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure
Mechanism of Action
Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. In the brain, dopamine actas as an agonist to the five dopamine receptor subtypes (D!, D2, D3, D4, D5).
Pharmacokinetics
- Absorption
- Dopamine is rapidly absorbed from the small intestine.
- Distribution
- Metabolism
- Biotransformation of dopamine proceeds rapidly to yield the principal excretion products, 3-4-dihydroxy-phenylacetic acid (DOPAC) and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid, HVA).
- Elimination
Toxicity
LD50 oral mice = 1460 mg/kg, LD50 oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.
Active Ingredient/Synonyms
2-(3,4-dihydroxyphenyl)ethylamine | 3-Hydroxytyramine | 3,4-Dihydroxyphenethylamine | 4-(2-aminoethyl)-1,2-benzenediol | 4-(2-Aminoethyl)benzene-1,2-diol | 4-(2-aminoethyl)catechol | 4-(2-aminoethyl)pyrocatechol | Dopamina | Dopamine | Dopaminum | Oxytyramine | Dopamine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.