Product Information
Registration Status: ActiveVASOPRESSIN INJECTION USP 20 U/ML is approved to be sold in Singapore with effective from 1995-09-19. It is marketed by FRESENIUS KABI (SINGAPORE) PTE LTD, with the registration number of SIN08350P.
This product contains Vasopressin 20 u/ml in the form of INJECTION. It is approved for SUBCUTANEOUS, INTRAMUSCULAR use.
This product is manufactured by AMERICAN PHARMACEUTICAL PARTNERS INC in UNITED STATES.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation
Indication
For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Mechanism of Action
Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Active Ingredient/Synonyms
Vasopressin, unspecified | Vasopressin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.