Product Information
Registration Status: ActiveVELBASTINE FOR INJECTION 10mg/VIAL is approved to be sold in Singapore with effective from 1999-06-24. It is marketed by SHOEI UNIVERSAL CORPORATION PTE LTD, with the registration number of SIN10987P.
This product contains Vinblastine 10mg/vial in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.
This product is manufactured by KOREA UNITED PHARMACEUTICAL INC in KOREA, and in REPUBLIC OF.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Description
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Indication
For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Mechanism of Action
The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
Toxicity
Oral, mouse: LD50 = 423 mg/kg; Oral, rat: LD50 = 305 mg/kg.
Active Ingredient/Synonyms
Vinblastin | Vinblastina | Vinblastine | Vinblastinum | Vincaleukoblastine | Vinblastine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.