Product Information
Registration Status: ActiveSIN08883P
VISIPAQUE INJECTION 320MGI/ML is approved to be sold in Singapore with effective from 1996-08-28. It is marketed by GE HEALTHCARE PTE LTD, with the registration number of SIN08883P.
This product contains Iodixanol 652mg/ml in the form of INJECTION. It is approved for INTRAVENOUS, INTRA-ARTERIAL, INTRATHECAL use.
This product is manufactured by GE HEALTHCARE IRELAND LIMITED (by Parametric Release) in IRELAND,GE HEALTHCARE AS (by Parametric Release) in NORWAY, andGE HEALTHCARE (SHANGHAI) CO. in CHINA.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents.
Indication
Iodixanol is a contrast agent during coronary angiography.
Mechanism of Action
Organic iodine compounds attenuate x-rays as they pass through the body, thereby allowing the body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intravascular administration, iodixanol makes opaque those internal structures in its path of flow, allowing their visualization until significant hemodilution and elimination occur.
Toxicity
Non-ionic radiocontrast agents like iodixanol are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
Active Ingredient/Synonyms
5,5'-((2-Hydroxytrimethylene)bis(acetylimino))bis(N,n'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide) | Indixanol | Iodixanolum | Iodixanol |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.