Product Information
Registration Status: ActiveSIN10983P
WELLBUTRIN SR TABLET 150mg is approved to be sold in Singapore with effective from 1999-06-16. It is marketed by GLAXOSMITHKLINE PTE LTD, with the registration number of SIN10983P.
This product contains Bupropion 150mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by GlaxoSmithKline LLC d/b/a GlaxoSmithKline in UNITED STATES,GLAXOSMITHKLINE AUSTRALIA PTY LTD (Primary and Secondary packager) in AUSTRALIA, andGlaxoSmithKline Pharmaceuticals S.A. (Primary and Secondary Packager) in POLAND.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.
Indication
For the treatment of depression and as aid to smoking cessation.
Mechanism of Action
Bupropion selectively inhibits the neuronal reuptake of dopamine, norepinephrine, and serotonin; actions on dopaminergic systems are more significant than imipramine or amitriptyline whereas the blockade of norepinephrine and serotonin reuptake at the neuronal membrane is weaker for bupropion than for tricyclic antidepressants. The increase in norepinephrine may attenuate nicotine withdrawal symptoms and the increase in dopamine at neuronal sites may reduce nicotine cravings and the urge to smoke. Bupropion exhibits moderate anticholinergic effects.
Pharmacokinetics
- Absorption
- For sustained release, peak plasma concentrations are achieved within 3 hours.
- Distribution
- Metabolism
- Reduction of the carbonyl groupand/or hydroxylation of the tert-butyl group of bupropion.
- Elimination
Toxicity
Symptoms of overdose include seizures, hallucinations, loss of consciousness, tachycardia, and cardiac arrest.
Active Ingredient/Synonyms
Amfebutamone | Bupropion |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.