Product InformationRegistration Status: Active
ZAFIBRAL TABLET 200mg is approved to be sold in Singapore with effective from 1998-08-10. It is marketed by MEDOCHEMIE SINGAPORE PTE LTD, with the registration number of SIN10217P.
This product contains Bezafibrate 200mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by MEDOCHEMIE LTD in CYPRUS.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Antilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins. [PubChem]
For the treatment of primary hyperlipidaemia types IIa, IIb, III, IV and V (Fredrickson classification) corresponding to groups I, II and III of the European Atherosclerosis Society guidelines - when diet alone or improvements in lifestyle such as increased exercise or weight reduction do not lead to an adequate response. Also for the treatment of secondary hyperlipidaemias, e.g. severe hypertriglyceridemias, when sufficient improvement does not occur after correction of the underlying disorder (e.g. diabetes mellitus).
Mechanism of Action
Like the other fibrates, bezafibrate is an agonist of PPARα; some studies suggest it may have some activity on PPARγ and PPARδ as well.
- Bezafibrate is almost completely absorbed after oral administration. The relative bioavailability of bezafibrate retard compared to the standard form is about 70%.
2-(P-(2-(P-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid | Befizal | Bezafibrat | Bezafibrato | Bezafibratum | Bezalip | Bezatol sr (tn) | Cedur | Bezafibrate |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.