Product Information
Registration Status: ActiveSIN15317P
ZERBAXA POWDER FOR SOLUTION FOR INJECTION 1G/0.5G is approved to be sold in Singapore with effective from 2017-08-14. It is marketed by MSD PHARMA (SINGAPORE) PTE LTD, with the registration number of SIN15317P.
This product contains Ceftolozane 1000mg, and Tazobactam 500mg in the form of INJECTION, POWDER, FOR SOLUTION. It is approved for INTRAVENOUS use.
This product is manufactured by Steri-Pharma in UNITED STATES, and LLC in ITALY.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Ceftolozane is a semi-synthetic beta-lactam antibiotic. It was approved by the FDA in January 2015 for use in combination with tazobactam for the treatment of: -Complicated Intra-abdominal Infections, used in combination with metronidazole. -Complicated Urinary Tract Infections, including Pyelonephritis. Ceftolozane/tazobactam is marketed under the brand name Zerbaxa™ by Cubist Pharmaceuticals U.S, which effective January 22, 2015, is now a wholly owned subsidiary of Merck & Co., Inc.
Indication
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Mechanism of Action
Ceftolozane belongs to the cephalosporin class of antibacterial drugs. The bactericidal action of ceftolozane results from inhibition of cell wall biosynthesis, and is mediated through binding to penicillin-binding proteins (PBPs). Ceftolozane is an inhibitor of PBPs of P. aeruginosa (e.g., PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3).
Active Ingredient/Synonyms
(6R,7R)-3-([3-Amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl)-7-([(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | Ceftolozane |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.
Indication
Used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action.
Mechanism of Action
Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
Active Ingredient/Synonyms
CL-298741 | Tazobactam | YTR-830H | Tazobactam |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.