Product Information
Registration Status: ActiveSIN01506P
ZOLADEX DEPOT INJECTION 3.6mg/SYRINGE is approved to be sold in Singapore with effective from 1988-05-25. It is marketed by ASTRAZENECA SINGAPORE PTE LTD, with the registration number of SIN01506P.
This product contains Goserelin 3.6mg/syringe in the form of INJECTION. It is approved for SUBCUTANEOUS use.
This product is manufactured by ASTRAZENECA UK LTD in UNITED KINGDOM.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.
Indication
Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty.
Mechanism of Action
Goserelin is a synthetic decapeptide analogue of LHRH. Goserelin acts as a potent inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. The result is sustained suppression of LH and serum testosterone levels.
Pharmacokinetics
- Absorption
- Inactive orally, rapidly absorbed following subcutaneous administration.
- Distribution
- * 44.1 ± 13.6 L [subcutaneous administration of 250 mcg]
- Metabolism
- Hepatic
- Elimination
Clearance
* 121 +/- 42.4 mL/min [prostate cancer with 10.8 mg depot]
Toxicity
No experience of overdosage from clinical trials.
Active Ingredient/Synonyms
Goserelin | Goserelin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.