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ZOLADEX LA DEPOT INJECTION 10.8mg/SYRINGE

Product Information

Registration Status: Active

SIN09793P

ZOLADEX LA DEPOT INJECTION 10.8mg/SYRINGE is approved to be sold in Singapore with effective from 1998-04-06. It is marketed by ASTRAZENECA SINGAPORE PTE LTD, with the registration number of SIN09793P.

This product contains Goserelin 10.8mg/syringe in the form of INJECTION. It is approved for SUBCUTANEOUS use.

This product is manufactured by ASTRAZENECA UK LTD in UNITED KINGDOM.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.

Indication

Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty.

Mechanism of Action

Goserelin is a synthetic decapeptide analogue of LHRH. Goserelin acts as a potent inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. The result is sustained suppression of LH and serum testosterone levels.

Pharmacokinetics

Absorption
Inactive orally, rapidly absorbed following subcutaneous administration.
Distribution
* 44.1 ± 13.6 L [subcutaneous administration of 250 mcg]
Metabolism
Hepatic
Elimination

Clearance

* 121 +/- 42.4 mL/min [prostate cancer with 10.8 mg depot]

Toxicity

No experience of overdosage from clinical trials.

Active Ingredient/Synonyms

Goserelin | Goserelin |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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