Product Information
Registration Status: ActiveSIN13647P
ZYLET STERILE OPHTHALMIC SUSPENSION is approved to be sold in Singapore with effective from 2009-04-05. It is marketed by BAUSCH & LOMB (SINGAPORE) PTE LTD, with the registration number of SIN13647P.
This product contains Loteprednol Etabonate Sterile 5mg/ml, and Tobramycin 3mg/ml in the form of SUSPENSION, STERILE. It is approved for OPHTHALMIC use.
This product is manufactured by Bausch & Lomb in UNITED STATES.
It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.
Description
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by the same species. [PubChem]
Indication
For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.
Mechanism of Action
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.
Pharmacokinetics
- Absorption
- The bioavailability of tobramycin may vary because of individual differences in nebulizer performance and airway pathology.
- Distribution
- Metabolism
- Elimination
Toxicity
LD50=441mg/kg (s.c. in mice)
Active Ingredient/Synonyms
3'-Deoxykanamycin b | Nebramycin 6 | Nebramycin factir 6 | Nebramycin-Faktor 6 | O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine | Tobracin (tn) | Tobramicina | Tobramycin | Tobramycine | Tobramycinum | Tobrex (tn) | Tobramycin |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.