X

DESOWEN CREAM 0.05%

Product Information

Registration Status: Active

SIN08252P

DESOWEN CREAM 0.05% is approved to be sold in Singapore with effective from 1995-04-07. It is marketed by GALDERMA SINGAPORE PTE LTD, with the registration number of SIN08252P.

This product contains Desonide 0.05% in the form of CREAM. It is approved for TOPICAL use.

This product is manufactured by LABORATOIRES GALDERMA in FRANCE.

It is a has been granted the exemption for supply without a presciption if it met certain criteria.

Reclassified Info

Product Reference
Loading...


Description

A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. [PubChem]

Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.

Mechanism of Action

Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Pharmacokinetics

Absorption
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin may increase percutaneous absorption.
Distribution
Metabolism
Elimination

Active Ingredient/Synonyms

11beta,21-Dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione | 11beta,21-Dihydroxy-16alpha,17-isopropylidenedioxypregna-1,4-diene-3,20-dione | 11beta,21-Dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione | 16alpha-Hydroxyprednisole-16,17-acetonide | 16alpha-Hydroxyprednisolone-16alpha,17-acetonide | 16alpha,17alpha-Isopropylidenedioxyprednisolone | Desfluorotriamcinolone acetonide | Desonida | Desonidum | Desonide |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

Pharmfair.com uses cookies to improve your browsing experience. We'll assume you're ok with this, but you can opt-out if you wish. Peace!